OMIM Entry - # 603903 - SICKLE CELL ANEMIA

The Sickle Cell Association of Ontario (SCAO) is a non-profit charitable organization, established in 1981 after it became evident that there was a need to educate the public about sickle cell anemia. Also, to provide moral support to parents and families of children, spouses, other relatives and individuals who suffer from sickle cell anemia.

RESEARCH PAGE - American Sickle Cell Anemia …

How I treat renal complications in sickle cell disease. Sharpe CC1, Thein SL.

sickle cell disease and sickle cell trait: variation ..

Sickle Cell Disease (SCD) is the most common serious genetic disease in Africa. Ghana and other countries in West and Central Africa have the highest prevalence of SCD and related disorders in the world. In Ghana about 2% of newborns have sickle cell disease which translates to about 16,000 to 18,000 children born annually with SCD, with 20% – 25 % born as trait or carriers.

Sickle-cell trait is often referred to as sickle-cell anemia.

Some simple examples of this immigration and residence information are inorder. Towns such as Palermo, Castrogiovanni (Enna), Calascibetta, Caltanissetta,Caltagirone, Caltabellotta,Racalmuto, Favara, Mistretta, Marsala, Mussomeli and Misilmeri were eitherfounded by Arabs or grew considerably under Arab domination, and bore Arabicnames (under the Greeks Palermo, from the Arabic Bal'harm, was Panormos). Thespecific mention of Arabs and the presence of Arabic given names and surnames wasevident in these places long after Frederick II banished a few thousand Arabs ofwestern Sicily to Apulia. As regards Jews present in many Sicilian localitiesuntil 1492, those who converted usually continued to name their childrenaccording to tradition (hence Abramo, Beniamino, Isacco, etc.) and to practiceprofessions traditionally associated with Jews in Sicily (dyers, bankers). Manyassumed distinctive surnames (Siino for Zion, Rabino for Rabbi) indicating aJewish orgin. Similar generalities about the permanence of Phoenician,Carthaginian, Greek and Roman populations in Sicily are valid. Where are thesepeoples today? Genetically (so to speak), they are represented in the modernSicilians --an amalgamated group of European and Mediterranean peoples. However,as we shall see, genetics and ethnic identity are two distinct ideas.

6/27: Beta-globin Haplotype Analysis in Children with Sickle Cell Anemia
Environmental tobacco smoke and airway obstruction in children with sickle cell anemia.

a human with sickle-cell anemia : ..

The ASH SCD guidelines will expand on guidelines published by the National Institutes of Health’s National Heart, Lung, and Blood Institute (NHLBI). The NHLBI’s EvidenceBased Management of Sickle Cell Disease: Expert Panel Report, 2014 provides useful guidance and information for primary care, emergency, and other clinicians who may be unfamiliar with this rare disease. The ASH guidelines will provide clinical recommendations for hematologists and other specialists. The ASH guidelines will also take into account new evidence available since the publication of the NHLBI guidelines and will be continually updated to present the latest in optimal care strategies.

6/27: Beta-globin Haplotype Analysis in Children with Sickle Cell Anemia

Dec 03, 2009 · Sickle cell anemia, ..

Platelets. 2014 Dec 30:1-4. [Epub ahead of print]

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Abstract The severe pain, ischemia and organ damage that characterizes sickle cell disease (SCD) is caused by vaso-occlusion, which is the blockage of blood vessels by heterotypic aggregates of sickled erythrocytes and other cells. Vaso-occlusion is also a vasculopathy involving endothelial cell dysfunction, leukocyte activation, platelet activation and chronic inflammation resulting in the multiple adhesive interactions between cellular elements. Since platelets mediate inflammation as well as thrombosis via release of pro- and anti-inflammatory molecules, we hypothesized that platelets may play an active inflammatory role in SCD by secreting increased amounts of cytokines. Since platelets have been shown to contain mRNA and actively produce proteins, we also hypothesized that SCD platelets may contain increased cytokine mRNA. In this cross-sectional study, we sought to compare both the quantity of cytokines secreted and the cytokine mRNA content, between SCD and control platelets. We measured the secretion of Th1, Th2, and Th17-related cytokines from platelets in a cohort of SCD patients. We simultaneously measured platelet mRNA levels of those cytokines. Platelets from SCD patients secreted increased quantities of IL-1β, sCD40L, and IL-6 compared to controls. Secretion was increased in patients with alloantibodies. Additionally, mRNA of those cytokines was increased in SCD platelets. Platelets from sickle cell patients secrete increased amounts of inflammatory cytokines, and contain increased cytokine mRNA. These findings suggest a novel immunological role for platelets in SCD vasculopathy, in addition to their thrombotic role, and strengthen the rationale for the use of anti-platelet therapy in SCD.

Association Between Baseline Fetal Hemoglobin Levels and Incidence of Severe Vaso-Occlusive Pain Episodes in Children With Sickle Cell Anemia.

Nov 09, 2011 · Sickle Cell Anemia Essays (Examples) ..

Kutlar completed an extensive historical review of patient and study outcomes in preparation for the lecture honoring the late Howard University physician who made it his mission to improve the lives of children with sickle cell disease. Scott's contributions include prompting the National Sickle Cell Control Act of 1972, which established the first federally-funded comprehensive sickle cell centers, including the one at MCG led by Dr. Titus H.J. Huisman.