Case Study: Leukemia and the discovery of cancer stem cells (CSCs)

Data from a case–control study do not by themselves permit estimation of absolute risks. Therefore, we have illustrated our results on the risk of fatal ischemic heart disease by combining them with recent data on rates of death from ischemic heart disease for the 15 westernmost countries of the European Union combined (Table S11 in the ). We have also illustrated the effect of radiotherapy for breast cancer on the risk of an acute coronary event (i.e., a major coronary event or unstable angina) by assuming that for women younger than 50 years of age, those 50 to 59 years of age, those 60 to 69 years of age, and those 70 to 79 years of age, the rates of acute coronary events are 6 times, 5 times, 3 times, and 2 times the rates of death from ischemic heart disease, respectively. The resulting baseline lifetime risk estimates are similar to recent estimates for the United States.

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Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study

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Major coronary events included myocardial infarction, coronary revascularization, and death from ischemic heart disease. The values for the solid line were calculated with the use of dose estimates for individual women. The circles show values for groups of women, classified according to dose categories; the associated vertical lines represent 95% confidence intervals. All estimates were calculated after stratification for country and for age at breast-cancer diagnosis, year of breast-cancer diagnosis, interval between breast-cancer diagnosis and first major coronary event for case patients or index date for controls (all in 5-year categories), and presence or absence of a cardiac risk factor. The radiation categories were less than 2, 2 to 4, 5 to 9, and 10 Gy or more, and the overall averages of the mean doses to the heart of women in these categories were 1.4, 3.4, 6.5, and 15.8 Gy, respectively.

Cellular Phones - American Cancer Society

We conducted a population-based case–control study of major coronary events (i.e., myocardial infarction, coronary revascularization, or death from ischemic heart disease) in 2168 women who underwent radiotherapy for breast cancer between 1958 and 2001 in Sweden and Denmark; the study included 963 women with major coronary events and 1205 controls. Individual patient information was obtained from hospital records. For each woman, the mean radiation doses to the whole heart and to the left anterior descending coronary artery were estimated from her radiotherapy chart.

View Notes - Breast Cancer Case Study with Answers(1) from NURS 1538 at El Centro College
Case Study Looks at Adherence Concerns of Woman With Metastatic Breast Cancer on Oral Regimen

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In both countries, women without histopathological confirmation of breast cancer, with bilateral or metastatic disease at the time of diagnosis, or with a history of cancer (excluding nonmelanoma skin cancer) or previous radiotherapy to the thoracic area were excluded. All other women who received radiotherapy were cross-matched with nationwide registers of diagnosis at the time of hospital discharge and cause of death (up to 2002 in Sweden and 2007 in Denmark). Women whose primary diagnosis was a major coronary event that occurred after a diagnosis of breast cancer but before any recurrence or diagnosis of a second cancer were classified as case patients. Whenever possible, hospital cardiology or autopsy records were reviewed, and if the case-defining event was refuted, the woman was excluded from the study. For each remaining case patient, we defined “time period” as the time from breast-cancer diagnosis to the time of first major coronary event. Controls (one per case patient in Sweden and two per case patient in Denmark) were selected at random from all eligible women in the study population. Eligibility criteria for controls included fulfillment of the matching criteria (country of residence, age at the time of breast-cancer diagnosis, and year of diagnosis, with both age and year matched within 5 years); receipt of radiotherapy; and no recurrence of breast cancer, no diagnosis with another cancer, and no major coronary event before the index date (defined as the date of breast-cancer diagnosis plus the time period of the matched case).

Aug 12, 2008 · Case-control study of lung cancer risk from residential radon exposure in Worcester County, Massachusetts. with 5 comments

Talcum Powder and Cancer - American Cancer Society

34. Darby SC, McGale P, Taylor CW, Peto R. Long-term mortality from heart disease and lung cancer after radiotherapy for early breast cancer: prospective cohort study of about 300 000 women in US SEER cancer registries. ;6:-

Risk of Ischemic Heart Disease in Women after …

Major coronary events included myocardial infarction, coronary revascularization, and death from ischemic heart disease. The values for the solid line were calculated with the use of dose estimates for individual women. The circles show values for groups of women, classified according to dose categories; the associated vertical lines represent 95% confidence intervals. All estimates were calculated after stratification for country and for age at breast-cancer diagnosis, year of breast-cancer diagnosis, interval between breast-cancer diagnosis and first major coronary event for case patients or index date for controls (all in 5-year categories), and presence or absence of a cardiac risk factor. The radiation categories were less than 2, 2 to 4, 5 to 9, and 10 Gy or more, and the overall averages of the mean doses to the heart of women in these categories were 1.4, 3.4, 6.5, and 15.8 Gy, respectively.